Symbol
Name
ID

Insr
insulin receptor
MGI:96575

Phenotype annotations related to endocrine/exocrine glands

Darker colors indicate more annotations

Human Phenotypes	Type II diabetes mellitus	Hyperinsulinemia	Fasting hyperinsulinemia	Hyperinsulinemic hypoglycemia	Pancreatic islet-cell hyperplasia	Elevated circulating insulin:C-peptide ratio	Increased circulating renin level	Hyperaldosteronism	Central hypothyroidism	Precocious puberty
Disease(s) Associated with INSR	Type II diabetes mellitus	Hyperinsulinemia	Fasting hyperinsulinemia	Hyperinsulinemic hypoglycemia	Pancreatic islet-cell hyperplasia	Elevated circulating insulin:C-peptide ratio	Increased circulating renin level	Hyperaldosteronism	Central hypothyroidism	Precocious puberty
Donohue syndrome
familial hyperinsulinemic hypoglycemia 5
type 2 diabetes mellitus

Mouse Phenotypes

abnormal pancreatic islet morphology

abnormal pancreatic beta cell morphology

decreased pancreatic beta cell mass

increased pancreatic beta cell mass

decreased pancreatic beta cell number

pancreatic islet hyperplasia

enlarged gallbladder

decreased corpora lutea number

decreased tertiary ovarian follicle number

abnormal seminiferous tubule morphology

decreased Leydig cell number

decreased insulin secretion

increased insulin secretion

Availability

Mouse Genotype

Insr^M2Btlr/Insr^M2Btlr

Insr^tm1Dac/Insr⁺

Insr^tm1Khn/Insr^tm1Khn
Tg(Nes-cre)1Kln/0 (conditional)

Insr^tm1Khn/Insr^tm1Khn
Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
Tg(Ins2-cre)25Mgn/0 (conditional)

Insr^tm1Khn/Insr^tm1Khn
Tg(Ins2-cre)25Mgn/0 (conditional)

Insr^tm1Khn/Insr^tm1Khn
Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ (conditional)

Insr^tm1Khn/Insr^tm1Khn
Tg(Slc2a4-cre)546Dac/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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